Yes, while generally safe, Naltrexone can have serious side effects, though rare. These include:Liver damage: Naltrexone has a risk of liver injury, especially at excessive doses or in patients with pre-existing liver conditions. Your provider will assess your liver health.Opioid overdose risk: If you attempt to overcome the Naltrexone blockade by taking large amounts of opioids, it can lead to severe opioid intoxication, respiratory depression, coma, or death. After discontinuing Naltrexone, your tolerance to opioids may be reduced, increasing the risk of overdose if you relapse.Depression/suicidal thoughts: Individuals with substance use disorders can be at higher risk for depression and suicidal thoughts. If you experience new or worsening depression or suicidal thoughts, contact your provider immediately.Precipitated withdrawal: As mentioned, taking Naltrexone while opioids are in your system will cause severe withdrawal.Always inform your healthcare provider about all medications you are taking and any pre-existing medical conditions.
.png)
